ANTİCOAGULANT AND ANTİLİPAEMİC ACTİVİTİES OF POLYSACCHARİDES FROM MARİNE ALGAE

Anticoagulant and antilipaemic activities of polysaccharides from marine algae

Kasım Cemal Güven, Burak Coban, Ekrem Sezik

Turkish Marine Research Foundation (TUDAV), PK 10, Beykoz, Istanbul, TURKEY
Department of Chemistry, Bulent Ecevit University, Incivez, 67100 Zonguldak, TURKEY
Institute of Health Sciences, Yeditepe University, 34755, Istanbul, TURKEY

Abstract

In this review the research on the anticoagulant and antilipaemic activity of sulfated and synthetically modified polysaccharides extracted from marine macro algae between 1913 and 2018 was summarized and the results were compared with a long known natural polysaccharide from animal sources, heparin which contain N-sulfate group. The highest anticoagulant activity of algal sulfated polysaccharide was obtained from Dictiyota menstrualis, red alga, found to be 4.8 times more active than heparin. Antilipaemic activity of some algal sulfated polysaccharides showed similar activity as heparin.

Keywords: Anticoagulant, antilipaemic, polysaccharides

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